Drug Interactions

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Dosage :

Try to follow your dosing schedule properly. Contact your doctor and get opined on how to continue the medicine further, if you miss any dose. And, if it is nearly the time of next dose, skip the missed dose and take the next dose on prescribed time. Never double your dose, which may lead to harmful side effects

Interactions :

Phenytoin Dilantin and thioridazine Mellaril markedly decrease the amount of Quetiapine that is absorbed from the intestine and thereby reduces its effectiveness. Therefore patients taking phenytoin or thioridazine may require higher doses of Quetiapine.

Quetiapine can cause hypotension, low blood pressure and therefore increase the blood pressure lowering the effects of antihypertensive drugs. Quetiapine can increase the sedating effects of other drugs that sedate. Such drugs include narcotic pain relievers e.g. Percocet barbiturates sedatives such as alprazolam Xanax and clonazepam Klonopin ethanol and blood pressure drugs that can cause orthostatic hypotension such as prazosin Minipress and terazosin Hytrin.

Quetiapine is eliminated from the body by an enzyme in the liver called cytochrome P450 3A. There is a concern that drugs that strongly interfere with the enzyme e.g. ketoconazole Nizoral itraconazole Sporanox fluconazole Diflucan and erythromycin clarithromycin Biaxin nefazodone Serzone verapamil Calan Isoptin Verelan or diltiazem Cardizem Tiazac Dilacor may cause elevated and toxic levels of Quetiapine.